Molecule- SPK-DJ115

1. Potent TLK1 inhibitor non-ATP dependent inhibitor with an IC50 of 7.2µM in ADP-Glo kinase assay.
2. Cytotoxic towards Prostate cancer, Glioblastoma, and breast cancer with the following GI50 values:
LNCaP- 2.7µM
DU145-6.5 µM
LN227-8.4 µM
MCF-7- 15.5 µM
MDA-MB-231- 15.1 µM
3. Inhibits cellular TLK1 by reduced phosphorylation levels of pRad9 at 0.5 µM.
4. Suppresses colony formation ability and induces apoptosis of LNCaP cells when administered along with Bicalutamide.