Molecule- SPK-DJ29
SPK-DJ29 (SPK9)
Biological activity:
1. Inhibits TLK1 kinase activity by 60%.
2. Inhibits cellular TLK1 by reduced phosphorylation levels of pRad9 at 5 µM.
3. Cytotoxic towards Prostate cancer and Glioblastoma.
LNCaP- 3.8µM
DU145-19.1 µM
LN227-14.1 µM
4. Suppresses colony formation ability of LNCaP cells when administered along with Bicalutamide.
Biological activity:
| Molecular Weight | 477.58 g/mol | ||
| Appearance | White Solid | ||
| Storage | 20ºC for long term, 4ºC for short term use | ||
| Solubility | 50 mM in DMSO | ||
| Stability | Solid stable up to 2.5 years after synthesis | ||
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