1. SPK-HD-77 is a potent Helicobacter pylori growth inhibitor, with a minimum inhibitory concentration (MIC) of 0.804 µg/mL on the H. pylori strains ATCC 26695 and I10.
2. SPK-HD-77 is a good pre-clinical candidate (lead) with high plasma protein binding, moderate MLM stability, no CYP inhibition, and better bioavailability.
3. Further, stomach tissue analysis shows that compound availability is good in the stomach than in plasma.*